SS-31 50MG
MITOCHONDRIAL RESEARCH
MOTS-C 40MG
Mitochondrial and Cellular Energy Research, Research Peptide Pens
One pre-filled 40mg MOTS-C research pen for laboratory studies of how cells manage energy.
£110.00Free UK tracked delivery
Compare cellular-energy optionsMOTS-C, NAD+ and SS-31→
- Made fresh to order
- Batch documentation pending
- UK tracked delivery
- Order by 1pm on working days for same-day dispatch
- Results published when verified
Research Use Only
MOTS-c 40mg is a synthetic version of a 16-amino-acid peptide encoded in mitochondrial DNA, supplied in one pre-filled research pen. Every MOTS-c pen is prepared to order in the UK and shipped cold chain by tracked delivery.
MOTS-c was described in 2015 as a peptide encoded within the mitochondrial 12S rRNA gene, one of a small group of mitochondrial-derived peptides. Read MOTS-c vs SS-31 vs NAD+ to see how it compares with SS-31 and NAD+.
How MOTS-c is studied
In cell studies MOTS-c inhibited the folate cycle, which led to accumulation of the metabolite AICAR and activation of AMPK, a central energy sensor. Under metabolic stress it moved into the nucleus and was linked to changes in nuclear gene expression. Mouse studies have examined it in skeletal muscle, insulin signalling in high-fat-diet models and physical capacity in aged animals.
5 key research areas
- AMPK and the folate cycle. Cell studies linked MOTS-c to folate-cycle inhibition, AICAR accumulation and AMPK activation.
- Nuclear gene regulation. Under metabolic stress MOTS-c moved to the nucleus and was associated with changes in stress-response gene expression.
- Insulin signalling in skeletal muscle. Mice on a high-fat diet were used to study MOTS-c and skeletal muscle insulin sensitivity.
- Exercise and physical capacity. Studies measured MOTS-c levels after exercise and examined physical capacity in aged mice.
- Muscle protein targets. Recent work reported that MOTS-c binds and activates the kinase CK2 in skeletal muscle.
Selected published research
Peer-reviewed studies and reviews on MOTS-c, with PubMed IDs:
- Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. PMID 25738459
- Lee C, et al. (2016). MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radical Biology and Medicine. PMID 27216708
- Kim KH, et al. (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism. PMID 29983246
- Reynolds JC, et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. PMID 33473109
- Kumagai H, et al. (2024). MOTS-c modulates skeletal muscle function by directly binding and activating CK2. iScience. PMID 39559755
These references describe laboratory and animal research on MOTS-c. They are cited as scientific background only and do not make this research material suitable for human use.
What arrives
40mg pen
One pre-filled Apexion research pen
One pre-filled Apexion research pen
Single compound
MOTS-c, 16-amino-acid mitochondrial-derived peptide
MOTS-c, 16-amino-acid mitochondrial-derived peptide
Protected packaging
Discreet and tamper-evident
Discreet and tamper-evident
Batch traceability
Batch number on every pen; independent testing in progress
Batch number on every pen; independent testing in progress
Preparation and UK dispatch
- Made fresh to order after checkout
- Prepared and quality checked before dispatch
- Tracked Royal Mail delivery across the UK
- UK-based product and documentation support
Simple, secure checkout
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Independent testing is in progress; results will be published only when verified evidence is available.
Source-material testing record
A supporting source-material laboratory record is held, but the supplied Apexion summary does not show a numeric laboratory result. A stated purity specification is not a measured result.
Scope: This information concerns a submitted source-material sample. It does not certify an Apexion finished pen or establish a match to the pen batch.
View source-material record (PDF) →
The original laboratory report is available on request.
Research use only. This product is supplied for in-vitro laboratory research by qualified researchers. It is not a medicine, is not licensed by the MHRA, and is not intended for human or veterinary use, diagnosis or treatment.
| Content | 40 mg MOTS-c, one pre-filled research pen |
|---|---|
| Purity | ≥98% (HPLC), as stated in the independent laboratory documentation for the source material |
| CAS | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | ~2174.6 g/mol |
| Form | Pre-filled research pen |
| Origin | UK-stocked, tracked Royal Mail dispatch |
| Intended use | Laboratory research only. Not for human consumption. |
APEXION BIOLABS
Quality & Verification
Batch Verification Record
Independent analytical testing documentation for MOTS-c 40mg.
Verification statusIndependent analytical testing verified (source material)
Product & Record
| Product | MOTS-c 40mg |
|---|---|
| Apexion verification ID | AX-QV-MOTS-001 |
| Analytical laboratory | Janoshik Analytical |
| Documentation status | Supporting laboratory documentation available |
| Finished pen batch testing | In progress. Results will be published here once verified. |
Documented Analytical Information
| Material tested | MOTS-c, lyophilised source material |
|---|---|
| Purity specification | ≥ 98% - HPLC-verified specification stated in the supporting documentation |
| Independent analysis | Analytical testing performed by Janoshik Analytical |
Verification Statement
Apexion BioLabs has reviewed and recorded the supporting independent analytical documentation for this product. Laboratory analysis was performed by Janoshik Analytical. The original laboratory documentation is retained within Apexion quality records and is not altered or re-issued as an Apexion laboratory report.
Documentation Transparency
This record presents the analytical information supported by the corresponding laboratory documentation. Commercial supply-chain information is kept private, while the independent laboratory and documented analytical scope are presented clearly for customer verification.
The material identified in the supporting laboratory documentation is MOTS-c lyophilised source material. Only analytical tests documented by the laboratory are represented on this record.
Independent lab analysisSupporting documentationApexion verification record
Apexion BioLabs – Batch Verification RecordAX-QV-MOTS-001
| Documentation status | Independent source-material analysis available (Janoshik Analytical); finished-pen batch testing in progress |
|---|---|
| Test method | HPLC (purity and identity) |
| Analysis | Janoshik Analytical (independent laboratory) on the MOTS-c source material; testing of finished pen batches is in progress |
| Verification | Apexion verification record AX-QV-MOTS-001; the original laboratory documentation is held in Apexion's quality records |
Storage conditions
- Shipped cold chain to keep the pen cool in transit
- Long-term: −20 °C in a temperature-controlled environment
- Short-term: keep cool and stable (2–8 °C) and away from direct light
- Keep the pen sealed when not in use
- Avoid repeated temperature changes (freeze–thaw cycles)
Handling guidance
- Check that the packaging and tamper seal are intact on arrival
- Handle as little as possible, using standard laboratory practice
- Record the batch number for traceability
- Follow any batch-specific guidance supplied with your order
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene. It has been studied in cell and mouse models of AMPK signalling, insulin sensitivity and skeletal muscle metabolism. Apexion supplies a synthetic version for laboratory research only.
What is the difference between MOTS-c and SS-31?
MOTS-c is a natural peptide encoded in mitochondrial DNA and is studied mainly in metabolic signalling. SS-31 is a synthetic tetrapeptide designed to bind cardiolipin at the inner mitochondrial membrane. Both are supplied for research use only.
How much MOTS-c is in each pen?
Each pen contains 40 mg of MOTS-c in one pre-filled research pen. Every pen comes from a single batch and carries its batch number.
Is MOTS-c independently tested?
Every MOTS-c pen is made fresh after your order is placed, so each one is prepared and quality checked to order rather than taken from old stock. Independent third-party testing of MOTS-c is under way, and the batch Certificate of Analysis will be published as soon as the results are verified. Each pen carries a batch number, so its documentation can be traced.
Can MOTS-c be used in humans or animals?
No. This product is not a medicine and is not licensed by the MHRA. It is supplied strictly for in-vitro laboratory research, and is not for human or veterinary use, diagnosis or treatment.
How should MOTS-c be stored?
MOTS-c is shipped cold chain. On arrival, keep the pen sealed and store it at −20 °C for long-term storage, away from heat and direct light. Handle it as little as possible and follow any batch-specific guidance supplied with your order.
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