MOTS-C 40MG
METABOLIC RESEARCH
5-AMINO-1MQ 50MG
Metabolic Research, Research Peptide Pens
One pre-filled 50mg 5-Amino-1MQ research pen for laboratory studies of cell metabolism.
£129.99Free UK tracked delivery
- Made fresh to order
- Batch documentation pending
- UK tracked delivery
- Order by 1pm on working days for same-day dispatch
- Results published when verified
Research Use Only
5-Amino-1MQ 50mg (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), supplied in one pre-filled research pen. Every 5-Amino-1MQ pen is prepared to order in the UK and shipped cold chain by tracked delivery.
5-Amino-1MQ is not a peptide but a quaternary quinolinium compound. NNMT uses nicotinamide, a precursor in the salvage pathway for NAD+, so the two are often discussed together. Our research compound guide covers related compounds.
How 5-Amino-1MQ is studied
NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide. Mouse studies that knocked down NNMT in fat tissue linked the enzyme to cellular energy expenditure, NAD+ and SAM levels. 5-Amino-1MQ came out of a structure-activity study of NNMT inhibitors. It has been examined in cultured adipocytes, in mice on a high-fat diet and in aged muscle stem cells.
5 key research areas
- NNMT inhibition. Structure-activity work compared quinolinium analogues for their potency and selectivity against NNMT.
- NAD+ and methyl-donor metabolism. NNMT research examines how the enzyme affects nicotinamide, NAD+ and SAM levels in cells.
- Adipocyte metabolism. Cultured adipocytes were used to study the effect of NNMT inhibition on lipogenesis and intracellular NAD+.
- High-fat-diet mouse models. Mice on a high-fat diet were used to examine body weight, adipose tissue and plasma lipids during NNMT inhibition.
- Aged muscle stem cells. Studies in aged mice examined muscle stem cell activity after NNMT inhibition.
Selected published research
Peer-reviewed studies on NNMT and its inhibitors, with PubMed IDs:
- Kraus D, et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. PMID 24717514
- Neelakantan H, et al. (2017). Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. Journal of Medicinal Chemistry. PMID 28548833
- Neelakantan H, et al. (2018). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. PMID 29155147
- Neelakantan H, et al. (2019). Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology. PMID 30753815
These references describe laboratory and animal research on NNMT and 5-Amino-1MQ. They are cited as scientific background only and do not make this research material suitable for human use.
What arrives
50mg pen
One pre-filled Apexion research pen
One pre-filled Apexion research pen
Single compound
5-Amino-1MQ, small-molecule NNMT inhibitor
5-Amino-1MQ, small-molecule NNMT inhibitor
Protected packaging
Discreet and tamper-evident
Discreet and tamper-evident
Batch traceability
Batch number on every pen; independent testing in progress
Batch number on every pen; independent testing in progress
Preparation and UK dispatch
- Made fresh to order after checkout
- Prepared and quality checked before dispatch
- Tracked Royal Mail delivery across the UK
- UK-based product and documentation support
Simple, secure checkout
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Independent testing is in progress; results will be published only when verified evidence is available.
Research use only. This product is supplied for in-vitro laboratory research by qualified researchers. It is not a medicine, is not licensed by the MHRA, and is not intended for human or veterinary use, diagnosis or treatment.
| Content | 50 mg 5-Amino-1MQ, one pre-filled research pen |
|---|---|
| Purity | Independent testing in progress; results published on verification |
| CAS | 685079-15-6 |
| Molecular formula | C10H11N2+ |
| Molecular weight | ~159.2 g/mol |
| Form | Pre-filled research pen |
| Origin | UK-stocked, tracked Royal Mail dispatch |
| Intended use | Laboratory research only. Not for human consumption. |
Every 5-Amino-1MQ pen is made fresh after your order is placed, and each one is prepared and quality checked before dispatch. Independent third-party testing of 5-Amino-1MQ is under way. The batch Certificate of Analysis will be published here, and linked to your pen's batch number, as soon as results are verified. Read how we test and verify every batch on our Quality & Batch Verification page.
| Documentation status | Independent testing in progress |
|---|---|
| Test method | HPLC (purity and identity) |
| Analysis | Independent third-party laboratory, plus in-house QC on every pen |
| Verification | Batch number on every pen; COA linked by QR once published |
Storage conditions
- Shipped cold chain to keep the pen cool in transit
- Long-term: −20 °C in a temperature-controlled environment
- Short-term: keep cool and stable (2–8 °C) and away from direct light
- Keep the pen sealed when not in use
- Avoid repeated temperature changes (freeze–thaw cycles)
Handling guidance
- Check that the packaging and tamper seal are intact on arrival
- Handle as little as possible, using standard laboratory practice
- Record the batch number for traceability
- Follow any batch-specific guidance supplied with your order
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It has been studied in cultured adipocytes, mouse metabolic models and aged muscle stem cells. Apexion supplies it for laboratory research only.
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small quaternary quinolinium molecule, not a peptide. It is supplied in the same pre-filled research pen format as our peptides.
How is 5-Amino-1MQ related to NAD+?
NNMT uses nicotinamide, which cells also use to make NAD+. Researchers therefore study NNMT inhibitors such as 5-Amino-1MQ alongside NAD+ metabolism. We supply both for research use only.
Is 5-Amino-1MQ independently tested?
Every 5-Amino-1MQ pen is made fresh after your order is placed, so each one is prepared and quality checked to order rather than taken from old stock. Independent third-party testing of 5-Amino-1MQ is under way, and the batch Certificate of Analysis will be published as soon as the results are verified. Each pen carries a batch number, so its documentation can be traced.
Can 5-Amino-1MQ be used in humans or animals?
No. This product is not a medicine and is not licensed by the MHRA. It is supplied strictly for in-vitro laboratory research, and is not for human or veterinary use, diagnosis or treatment.
How should 5-Amino-1MQ be stored?
5-Amino-1MQ is shipped cold chain. On arrival, keep the pen sealed and store it at −20 °C for long-term storage, away from heat and direct light. Handle it as little as possible and follow any batch-specific guidance supplied with your order.
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