NEUROENDOCRINE RESEARCH
Kisspeptin 10mg
One pre-filled 10mg Kisspeptin research pen for laboratory studies of brain and hormone signalling.
£89.99Free UK tracked delivery from £100
- Made fresh to order
- Batch documentation pending
- UK tracked delivery
- Made fresh to order: dispatched within 1 to 2 working days
- Results published when verified
Research Use Only
Kisspeptin 10mg is synthetic Kisspeptin-10, the 10-amino-acid C-terminal fragment of the Kisspeptin peptides encoded by the KISS1 gene, supplied in one pre-filled research pen. Every Kisspeptin pen is prepared to order in the UK and shipped cold chain by tracked delivery.
Kisspeptin-10 (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) contains the sequence needed to activate the kisspeptin receptor, KISS1R (also called GPR54). Our research compound guide covers related neuropeptides and research compounds.
How Kisspeptin is studied
Kisspeptins were identified in 2001 as the natural ligands of GPR54, a receptor first described as an orphan. KISS1 had earlier been studied as a metastasis-suppressor gene. In 2003, loss-of-function mutations in GPR54 were found in people who did not go through puberty, which placed kisspeptin signalling at the top of the reproductive hormone axis. Animal studies then showed that Kisspeptin acts directly on GnRH neurons to trigger GnRH release.
5 key research areas
- KISS1R (GPR54) pharmacology. Receptor studies identified kisspeptins as the endogenous ligands of KISS1R.
- GnRH release. Rodent and sheep studies examined how Kisspeptin acts on hypothalamic GnRH neurons.
- Puberty genetics. Human genetic studies linked loss of GPR54 function to hypogonadotropic hypogonadism.
- Hypothalamic-pituitary-gonadal axis. Animal models measure LH and FSH responses to kisspeptin signalling.
- Metastasis-suppressor biology. KISS1 was first studied as a gene that suppresses metastasis in cancer cell models.
Selected published research
Peer-reviewed studies on kisspeptin and its receptor, with PubMed IDs:
- Ohtaki T, et al. (2001). Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. PMID 11385580
- Muir AI, et al. (2001). AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. Journal of Biological Chemistry. PMID 11387329
- de Roux N, et al. (2003). Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proceedings of the National Academy of Sciences of the USA. PMID 12944565
- Seminara SB, et al. (2003). The GPR54 gene as a regulator of puberty. New England Journal of Medicine. PMID 14573733
- Messager S, et al. (2005). Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proceedings of the National Academy of Sciences of the USA. PMID 15665093
These references describe laboratory, animal and human genetic research on kisspeptin and its receptor. They are cited as scientific background only and do not make this research material suitable for human use.
What arrives
10mg pen
One pre-filled Apexion research pen
One pre-filled Apexion research pen
Single compound
Kisspeptin-10, KISS1R agonist
Kisspeptin-10, KISS1R agonist
Protected packaging
Sealed and tamper-evident
Sealed and tamper-evident
Batch traceability
Batch number on every pen; independent testing in progress
Batch number on every pen; independent testing in progress
Preparation and UK dispatch
- Made fresh to order after checkout
- Prepared and quality checked before dispatch
- Tracked Royal Mail delivery across the UK
- UK-based product and documentation support
Simple, secure checkout
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Independent testing is in progress; results will be published only when verified evidence is available.
Research use only. This product is supplied for in-vitro laboratory research by qualified researchers. It is not a medicine, is not licensed by the MHRA, and is not intended for human or veterinary use, diagnosis or treatment.
| Content | 10 mg Kisspeptin-10, one pre-filled research pen |
|---|---|
| Purity | Independent testing in progress; results published on verification |
| CAS | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | ~1302.4 g/mol |
| Form | Pre-filled research pen |
| Origin | UK-stocked, tracked Royal Mail dispatch |
| Intended use | Laboratory research only. |
Every Kisspeptin pen is made fresh after your order is placed, and each one is prepared and quality checked before dispatch. Independent third-party testing of Kisspeptin is under way. The batch Certificate of Analysis will be published here, and linked to your pen's batch number, as soon as results are verified. Read how we test and verify every batch on our Quality & Batch Verification page.
| Documentation status | Independent testing in progress |
|---|---|
| Test method | HPLC (purity and identity) |
| Analysis | Independent third-party laboratory, plus in-house QC on every pen |
| Verification | Batch number on every pen; COA linked by QR once published |
Storage conditions
- Shipped cold chain to keep the pen cool in transit
- Long-term: −20 °C in a temperature-controlled environment
- Short-term: keep cool and stable (2–8 °C) and away from direct light
- Keep the pen sealed when not in use
- Avoid repeated temperature changes (freeze–thaw cycles)
Handling guidance
- Check that the packaging and tamper seal are intact on arrival
- Handle as little as possible, using standard laboratory practice
- Record the batch number for traceability
- Follow any batch-specific guidance supplied with your order
What is Kisspeptin?
Kisspeptins are peptides encoded by the KISS1 gene that activate the KISS1R (GPR54) receptor. This product is Kisspeptin-10, the shortest active fragment. It is studied in models of GnRH release and the reproductive hormone axis, and Apexion supplies it for laboratory research only.
What is the difference between Kisspeptin-10 and kisspeptin-54?
Both come from the same precursor. Kisspeptin-54 is the longer form; Kisspeptin-10 is its last 10 amino acids, which contain the sequence needed to activate KISS1R. This product is Kisspeptin-10.
How much Kisspeptin is in each pen?
Each pen contains 10 mg of Kisspeptin-10 in one pre-filled research pen. Every pen comes from a single batch and carries its batch number.
Is Kisspeptin independently tested?
Every Kisspeptin pen is made fresh after your order is placed, so each one is prepared and quality checked to order rather than taken from old stock. Independent third-party testing of Kisspeptin is under way, and the batch Certificate of Analysis will be published as soon as the results are verified. Each pen carries a batch number, so its documentation can be traced.
Can Kisspeptin be used in humans or animals?
No. This product is not a medicine and is not licensed by the MHRA. It is supplied strictly for in-vitro laboratory research, and is not for human or veterinary use, diagnosis or treatment.
How should Kisspeptin be stored?
Kisspeptin is shipped cold chain. On arrival, keep the pen sealed and store it at −20 °C for long-term storage, away from heat and direct light. Handle it as little as possible and follow any batch-specific guidance supplied with your order.
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